Late-Breakers

Be Among the first to hear the latest practice-changing breakthroughs at ACC.23/WCC. Hear top experts debate and discuss the outcomes of the trials and find out how it all fits into your practice. With five Late-Breaking Clinical Trial Sessions, two LBCT Deep Dive Sessions, and three Featured Clinical Research sessions, you'll leave ACC.23/WCC up to date on the newest clinical research.

Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402)
Saturday, March 4 9:30 – 10:30 a.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • CLEAR Outcomes Trial: Bempedoic Acid and Cardiovascular Outcomes in Statin Intolerant Patients at High Cardiovascular Risk
  • TRILUMINATE Pivotal: A Landmark Randomized Clinical Trial of Transcatheter Tricuspid Valve Edge-to-Edge Repair For Tricuspid Regurgitation
  • Statins TO Prevent the Cardiotoxicity From Anthracyclines: The STOP-CA Trial

Featured Clinical Research I (Session 403)
Saturday, March 4 Noon – 1:15 p.m. CT
Room 257 Hot Topics Channel

  • HALO Trial: Results From a Phase 2, Double-blind, Placebo-controlled Trial Evaluating the Efficacy and Safety of Baxdrostat in Patients With Uncontrolled Hypertension
  • Effect of Myocardial Viability, Percutaneous Coronary Intervention and Functional Recovery on Clinical Outcomes in the REVIVED-BCIS2 Randomized Trial
  • AIMI-HF Trial: Ischemia and Viability Imaging in Heart Failure: The Alternative Imaging Modalities in Ischemic Heart Failure Trial
  • Effect of Evolocumab on Coronary Plaque Characteristics in Stable Coronary Artery Disease: A Multimodality Imaging Study (the Yellow III Study)
  • On-site Computed Tomography-derived Fractional Flow Reserve to Guide the Management of Patients With Stable Coronary Artery Disease: The TARGET Randomized Trial

Joint American College of Cardiology/New England Journal of Medicine Late-Breaking Clinical Trials (Session 405)
Sunday, March 5 8 – 9:15 a.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • Minimally Invasive Versus Conventional Sternotomy For Mitral Valve Repair Surgery: An Expertise Based Multicentre Randomised Controlled Trial (UK Mini Mitral)
  • Transcatheter Edge-to-edge Repair of Functional Mitral Regurgitation in Heart Failure: Final Five-year Results From the COAPT Trial
  • Transcatheter Versus Surgical Aortic Valve Replacement in Aortic Stenosis Patients at Low Surgical Risk: 3-year Outcomes From the Evolut Low Risk Trial
  • BIOVASC: Complete Revascularization Strategies in Patients Presenting With Acute Coronary Syndromes and Multivessel Coronary Disease
  • RENOVATE-COMPLEX-PCI: Intravascular Imaging-guided Versus Angiography-guided Procedural Optimization in Complex Percutaneous Coronary Intervention

Late-Breaking Clinical Trials III (Session 406)
Sunday, March 5 9:45 – 11 a.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations For Heart Failure (BETTER CARE-HF): A Pragmatic, Cluster-randomized Trial Comparing Two Ambulatory Clinical Decision Support Tools
  • A Nationwide Randomized Trial of Electronically Delivered Nudges to Increase Influenza Vaccination Uptake: The NUDGE-FLU Trial
  • A Randomized Trial of a Personalized Clinical Decision Support Intervention to Improve Statin Prescribing in Patients With Atherosclerotic Cardiovascular Disease (PCDS Statin)
  • Translating Polygenic Risk For Coronary Artery Disease Into Clinically Actionable Information Using Causal A.I.
  • ACCESS: A Randomized Trial Assessing the Impact of Eliminating Copayment For High Value Preventive Medications For Low-income Seniors With Cardiovascular-related Chronic Diseases

Featured Clinical Research II (Session 407)
Sunday, March 5 12:15 – 1:30 p.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • RAPID-HF: Atrial Pacing For Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial
  • Association of a Low-carbohydrate High-fat (Ketogenic) Diet With Plasma Lipid Levels and Cardiovascular Risk in a Population-based Cohort
  • STREAM-2: Pharmaco-invasive Reperfusion Strategy With Half-dose Tenecteplase in Older St-elevation Myocardial Infarction Patients
  • Comparison of 3-month Versus 12-month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-eluting Stents With Ultrathin Struts And Advanced Polymer Technology: The HOST-IDEA Randomized Clinical Trial
  • Safety and Efficacy of Transcatheter Edge-to-Edge Mitral Repair in Degenerative Mitral Regurgitation: An Analysis Of The STS/ACC TVT Registry

Late-Breaking Clinical Trials Deep Dive I (Session 408)
Sunday, March 5 2 – 3:15 p.m. CT
Main Tent (Great Hall) Hot Topics Channel
Get even more insights from key clinical trials presented at ACC.23/WCC and find out what it all means for your patients.

Clinical and Investigative Horizons (Session 414)
Sunday, March 5 2 – 3:15 p.m. CT

  • Prediction of Preeclampsia Using High-Sensitivity Troponin I
  • Outcomes in High-risk Pulmonary Embolism Patients Undergoing FlowTriever Mechanical Thrombectomy: Results From The FLAME Study
  • Health 360x Registry: Equitable Access to Point of Care Decentralized Clinical Trials
  • Cardiovascular Disease and Mortality in Black Women Carrying the Amyloidogenic Val122ile Variant
  • Impact Of Remote Cardiac Device Monitoring on Green House Emissions: Data From the Global Cardiovascular Carbon Footprint (GCCF) Project

Joint American College of Cardiology/Journal of the American Medical Association Late-Breaking Clinical Trials (Session 409)
Monday, March 6 8:30 – 9:45 a.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • PULSED Field Ablation Treatment in Paroxysmal and Persistent Atrial Fibrillation Patients: Acute and Long-term Outcomes From the PULSED AF Pivotal Trial
  • Impact of Heart Failure Management Using Thoracic Fluid Monitoring From a Novel Wearable Sensor: Results of the Benefits of Microcor (μCor™) in Ambulatory Decompensated Heart Failure (BMAD) Trial
  • A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment For Acute Myocardial Infarction
  • Efficacy and Safety of Macitentan Tadalafil Fixed Dose Combination in Pulmonary Arterial Hypertension: Results From the Randomized Controlled Phase III A DUE Study
  • Coordinating Cardiology Clinics Randomized Trial of Interventions to Improve Outcomes (COORDINATE)-Diabetes: Primary Results

Late-Breaking Clinical Trials V (Session 410)
Monday, March 6 11 a.m. – 12:15 p.m. CT
Main Tent (Great Hall) Hot Topics Channel

  • Vigorous Exercise in Individuals With Hypertrophic Cardiomyopathy (HCM): Primary Results of the Prospective, Multinational Lifestyle and Exercise in HCM (LIVE-HCM) Study
  • Return-to-Play For Elite Level Athletes With Sudden Cardiac Death Predisposing Genetic Heart Diseases
  • Anticoagulation Strategies in Non-critically Ill Hospitalized Covid-19 Patients: Principal Outcomes of the Freedom Covid Anticoagulation Trial
  • The STELLAR Phase III Trial: A Study of Sotatercept in Combination With Background Therapy For the Treatment of Pulmonary Arterial Hypertension
  • Efficacy and Safety of the Oral PCSK9 Inhibitor, MK-0616, A Macrocyclic Peptide, in the Treatment of Hypercholesterolemia: A Phase 2b Randomized Placebo-Controlled Clinical Trial

Featured Clinical Research III (Session 411)
Monday, March 6 12:45 – 2 p.m. CT
La Nouvelle B Hot Topics Channel

  • Masters@Heart: Lifelong Endurance Exercise and Its Relationship With Coronary Atherosclerosis
  • Residual Inflammatory Risk in Contemporary Statin Treated Patients: A Collaborative Analyses Of 31,197 Participants in the PROMINENT, REDUCE-IT, and STRENGTH Trials
  • The LOADSTAR Trial: Comparison Between Targeted Low-Density Lipoprotein Cholesterol Level Based Versus High-Intensity Statin Therapy in Patients With Coronary Artery Disease
  • CAMEO-DAPA Trial: Evaluation of the Mechanism of Benefit For Dapagliflozin in Heart Failure With Preserved Ejection Fraction: An Invasive Hemodynamic Randomized Trial
  • Safety and Efficacy of Virtual Care Team Guided Therapeutic Optimization During Hospitalization in Patients With HFrEF: The IMPLEMENT-HF Study

Late-Breaking Clinical Trials Deep Dive II (Session 413)
Monday, March 6 2:30 – 3:45 p.m. CT
La Nouvelle B Hot Topics Channel
Get even more insights from key clinical trials presented at ACC.23/WCC and find out what it all means for your patients.

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