Late-Breakers

Be among the first to hear the latest practice-changing scientific breakthroughs at ACC.21. Hear top experts debate and discuss the outcomes of the hottest trials and see how it all fits into your practice. With five Late-Breaking Clinical Trial Sessions, three Featured Clinical Research Sessions, and two LBCT Deep Dive Sessions, ACC.21 will leave you up-to-date on the newest clinical research.

Joint American College of Cardiology and Journal of the American College of Cardiology Late-Breaking Clinical Trials I
Saturday, May 15 ● 9 – 10 a.m. ET
Hot Topics Channel

• PARADISE-MI: Prospective Arni Versus Ace Inhibitor Trial To Determine Superiority In Reducing Heart Failure Events After Myocardial Infarction
• ADAPTABLE Study: Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness Trial
• LAAOS III: The Left Atrial Appendage Occlusion Study III
• Randomized Atlantis Trial: Oral Anti-xa Anticoagulation After Trans-aortic Valve Implantation For Aortic Stenosis

Featured Clinical Research I
Saturday, May 15 ● 12:15 – 1:30 p.m. ET
Hot Topics Channel

• Results from the EXPLORER-HCM Randomized Clinical Trial: Health Status Benefits of Mavacamten In Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy
• A Report From the NCDR LAAO Registry: One-year Clinical Outcomes Following Watchman Transcatheter Left Atrial Appendage Occlusion For Stroke Prevention In Patients With Atrial Fibrillation
• Analysis Of Clinical Outcomes in the Node-301 Trial: Etripamil Nasal Spray Relieves Symptoms And Reduces Emergency Room Interventions In Patients With Paroxysmal Supraventricular Tachycardia (PSVT)
• Atlantis 4d Computed Tomography Substudy: Valve Thrombosis After Transcatheter Aortic-valve Replacement
• 30-day Results of the Triscend Study: Transfemoral Tricuspid Valve Replacement In Patients With Tricuspid Regurgitation
• Results From the Twilight Study: Sex-Specific Outcomes In High-Risk Patients Receiving Ticagrelor With Or Without Aspirin After Percutaneous Coronary Intervention

Joint American College of Cardiology and Journal of the American Medical Association Late-Breaking Clinical Trials II
Sunday, May 16 ● 8 – 9:30 a.m. ET
Hot Topics Channel

• Main Results From the DARE-19 Randomized Trial: Main Results From the DARE-19 Randomized Trial: Effects Of Dapagliflozin On Prevention Of Major Clinical Events And Recovery In Patients With Respiratory Failure Due To COVID-19
• VOYAGER PAD Trial: Reductions In Total Ischemic Events With Rivaroxaban In Patients With Symptomatic Pad After Revascularization
• A Phase 2 Trial Of The Efficacy And Safety Of Evinacumab In Patients With Severe Hypertriglyceridemia
• REHAB-HF Trial: A Novel Physical Rehabilitation Intervention For Older Patients With Acute Decompensated Heart Failure
• STRENGTH Trial: Relationship Between Omega-3 Fatty Acid Levels And Major Adverse Cardiovascular Outcomes In Patients With High Cardiovascular Risk
• PRADA Trial: Prevention Of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: Long-term Follow-up Of A 2 X 2 Factorial, Randomized, Placebo-controlled, Double-blind Clinical Trial Of Candesartan And Metoprolol

Joint American College of Cardiology and New England Journal of Medicine Late-Breaking Clinical Trials III
Sunday, May 16 ● 10:45 a.m. – 12:15 p.m. ET
Hot Topics Channel

• The FLOWER-MI Randomized Trial: Fractional Flow Reserve-guided Versus Angio-guided Multivessel Revascularization In ST-Elevation Myocardial Infarction Patients
• A Prospective, Multicenter, Randomized, Open-label Trial To Compare Efficacy And Safety Of Clopidogrel Versus Ticagrelor In Stabilized Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention
• Host Exam Randomized Controlled Trial: Aspirin Vs. Clopidogrel During Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention
• Late Outcomes Of A 1-hour High Sensitivity Troponin T Protocol In Suspected Acute Coronary Syndromes: A Randomized Clinical Trial
• Randomized Sham-controlled RADIANCE-HTN TRIO Trial: Endovascular Ultrasound Renal Denervation To Treat Hypertension Resistant To A Fixed Dose Triple Medication Pill

Featured Clinical Research II
Sunday, May 16 ● 2 – 3:30 p.m. ET
Hot Topics Channel

• SAFE-PAD Study: Initial Report From the Safety Assessment Of Femoropopliteal Endovascular Treatment With Paclitaxel-coated Devices Study
• One-year Follow-up of the Reality Randomized Clinical Trial: Effect Of A Restrictive Vs Liberal Blood Transfusion Strategy On Major Cardiovascular Events Among Patients With Acute Myocardial Infarction And Anemia
• World Alliance Societies Of Echocardiography COVID Study: Human Vs Machine Learning-based Echocardiography Analysis As Predictor Of Outcomes In Acute Covid-19 Patients
• Coalition ACTION Trial: Randomized Clinical Trial To Evaluate A Routine Full Anticoagulation Strategy In Patients With Coronavirus Infection (SARS-CoV-2) Admitted To Hospital
• Inspiration-S Double Blind Randomized Controlled Trial: Atorvastatin Versus Placebo In Critically-ill Patients With Covid-19
• ACC 2020 Well Being Study: Impact of COVID-19 on the Global Cardiovascular Workforce

Late-Breaker Deep Dive I
Sunday, May 16 ● 4:45 – 6 p.m. ET
Clinical Pathways Channel 1

Get more insight from key clinical trials presented at ACC.21 and find out what it all means for you and your patients.

Late-Breaking Clinical Trials IV
Monday, May 17 ● 8 – 9:30 a.m. ET
Hot Topics Channel

• Benefits Of Sodium Glucose Co-transporter-1/2 Inhibition With Sotagliflozin Across The Full Spectrum Of Ejection Fraction, Including Heart Failure With Preserved Ejection Fraction
• Primary Results of the Connect-hf Randomized Clinical Trial: Care Optimization Through Patient And Hospital Engagement Clinical Trial For Heart Failure
• Results of the LIFE Trial: Sacubitril/Valsartan (LCZ696) In Patients With Advanced Heart Failure And Reduced Ejection Fraction
• Pirfenidone In Heart Failure With Preserved Ejection Fraction
• Secondary Analysis From GALACTIC-HF: Impact Of Ejection Fraction On The Therapeutic Effect Of Omecamtiv Mecarbil In Patients With Heart Failure And Reduced Ejection Fraction

Late-Breaking Clinical Trials V
Monday, May 17 ● 10:45 a.m. – 12:15 p.m. ET
Hot Topics Channel

• Therapeutic Hypothermia Following Out-Of-Hospital Cardiac Arrest: A Randomized Trial Comparing Mild And Moderate Therapeutic Hypothermia
• Prague OHCA Study: Hyperinvasive Approach In Refractory Out-of-Hospital Cardiac Arrest: An Open-label Randomized Controlled Trial
• RAFT-AF: A Randomized Ablation-based Atrial Fibrillation Rhythm Control Versus Rate Control Trial In Patients With Heart Failure And High Burden Atrial Fibrillation
• Acute Alcohol Consumption And Discrete Atrial Fibrillation Events
• Finerenone And New Onset Of Atrial Fibrillation Or Flutter In Patients With Chronic Kidney Disease And Type 2 Diabetes

Featured Clinical Research III
Monday, May 17 ● 12:30 – 1:45 p.m. ET
Hot Topics Channel

• One-year Results of the American College Of Cardiology Global Heart Attack Treatment Initiative: Worldwide ST-elevation Myocardial Infarction Care
• ISCHEMIA Trial: Impact Of Completeness Of Revascularization On Clinical Outcomes In Patients With Stable Ischemic Heart Disease Treated With An Invasive Vs. Conservative Strategy
• Insights From the ISCHEMIA Trial: Impact Of Completeness Of Revascularization On Quality-of-life In Patients With Stable Ischemic Heart Disease
• Tailor-Pci Randomized Clinical Trial Follow-up Study: Effect Of Genotype-guided Oral P2y12 Inhibitors Vs Conventional Clopidogrel On Long-term Ischemic Outcomes After Percutaneous Coronary Intervention
• Effects Of Interleukin-6 Inhibition With Ziltivekimab On Biomarkers Of Inflammation Among Patients At High Risk For Atherosclerotic Events

Late-Breaker Deep Dive II
Monday, May 17 ● 2 – 3:30 p.m. ET
Hot Topics Channel

Get more insight from key clinical trials presented at ACC.21 and find out what it all means for you and your patients.